The handloom industry in India has witnessed steady growth over the past two decades, with Odisha emerging as a significant hub for local artisans and manufacturers. In today’s era of conscious consumerism, handloom products are in demand both nationally and internationally; however, retailers continue to face critical challenges in sustaining and expanding sales across online, offline, and omni-channels (both online and offline). This study provides a comparative analysis of Odisha’s handloom retailers, highlighting how offline sellers dominate due to cultural trust and tactile experiences, online retailers face barriers of competition and digital capability gaps, and omni retailers struggle with dual operational pressures. Drawing on primary data collected from 284 retailers through a structured survey, the findings reveal that while offline sales remain the most profitable, social media-driven commerce and omnichannel models present strong growth opportunities. The study offers targeted recommendations for strengthening trust, enhancing digital skills, optimizing store experiences, and leveraging government and NGO partnerships. Using the combination of tradition with modern retail strategies, Odisha’s handloom sector can enhance its resilience, profitability, and global visibility in the years ahead.